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The requirement that doors must remain closed at all times is fundamentally tied to their role in maintaining safety, security, and environmental control within healthcare facilities. Specifically, when force is applied to doors designed to stay closed, they must be able to effectively resist that force to prevent unauthorized access, contamination, or air pressure issues.

Choosing the option that states the doors must remain closed when force is applied highlights the importance of maintaining the integrity of these barriers. For example, many healthcare settings utilize specific doors as part of fire safety protocols or to protect sensitive areas from cross-contamination. The doors must be capable of closing and sealing properly, even if subjected to external forces, to ensure they fulfill their intended purpose and adhere to regulatory compliance.

In terms of the other options, while locking doors, ensuring they are unobstructed, and placing warning signs may be important for different reasons, they do not address the crucial function of maintaining closure in the presence of force, which is essential for the door's protective function.